HUNT4 Dental Health featured in GLIDE2
Do genetic variants have significance for the development of caries and periodontitis?
Background
Genetic risk factors play important roles in the etiology of oral diseases. Identifying relevant genetic variants and understanding their molecular biology may provide better prevention and treatment strategies. Our current understanding of oral health genomics suggests that dental caries and periodontitis are polygenic diseases, and very large sample sizes and informative phenotypic definitions are needed to detect signals and map associations across the human genome.
Purpose
Our overall goal is to join the international consortium GLIDE2 with HUNT4 Dental Health and perform genome-wide association studies (GWAS) of caries and periodontitis. GLIDE2 is established to investigate interactions between genes and lifestyle for oral health and includes more than 20 studies from multiple countries worldwide.
Methods
We will use data from HUNT4 Dental Health to define oral phenotypes and perform GWAS of caries and periodontitis. The summary results of GWAS in HUNT4 Dental Health will be delivered to the consortium for meta-analysis.
Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium
K Divaris, S Haworth, J R Shaffer, V Anttonen, J D Beck, Y Furuichi, B Holtfreter, D Jönsson, T Kocher, S M Levy, P K E Magnusson, D W McNeil, K Michaëlsson, K E North, U Palotie, P N Papapanou, P J Pussinen, D Porteous, K Reis, A Salminen, A S Schaefer, T Sudo, Y Q Sun, A L Suominen, T Tamahara, S M Weinberg, P Lundberg, M L Marazita, I Johansson.